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TCI Reagents

TCI Europe NV – Moving Your Chemistry Forward

TCI is a leading global manufacturer of fine chemicals for research and industry. We supply and manufacture more than 29,000 research chemicals using our own facilities. Many of these chemicals are highly specialised, including a large number of reagents available only through TCI.

TCI is able to supply a wide selection of Fine and Specialty Chemicals by drawing upon our expertise of manufacturing techniques. With proven production experience and varied reaction capabilities, which rank us among the best in the industry, TCI can supply most compounds in sizes ranging from milligram to bulk scale.

TCI is located near to our customers, allowing us to work alongside and react to local and international needs.

In pursuit of meeting customer demands, we have developed a worldwide network of effective communication and shared capability, which enables us to deliver our high quality reagents rapidly to customers across the globe from our offices and plants in North America, Europe, China and India.

We will continue to persevere in our efforts in “Moving Your Chemistry Forward".

In these Reagent Guides, TCI products have been categorized and classified according to research fields, reaction types, applications and basic structures.

  SOC

 Synthetic Organic Chemistry & Materials Chemistry - In this Reagent Guide, TCI products which are mainly used in the field of Synthetic Organic Chemistry and Materials Chemistry have been categorized and classified according to research fields, reaction types, applications and basic structures.
Classification examples:
Synthetic Organic Chemistry
Asymmetric Organocatalysts / Cross-coupling Reaction Using Transition Metal Catalysts / Condensation & Active Esterification
Materials Chemistry
Solar Cell Research Reagents / OLED / Photochromic Compounds
  BAS

 Bioscience & Analytical Science – In this Reagent Guide, TCI products which are mainly used in the field of Bioscience and Analytical Science have been categorized and classified, according to research fields, reaction types, applications and basic structures.
Classification examples:
Bioscience
Nucleosides / Amino Acids / Sugars / Lipids / Terpenes / Steroids / Antibodies
Analytical Science
GC Derivatizing Reagents / HPLC Labeling Reagents / HPLC Columns / Derivatization Reagents for MS
  RGC

 Reagents for Glyco Chemistry - Total of 900 products including 200 new products.
- Newly-lunched N-glycan (synthetic).
- Many oligosaccharides applicable to sugar-conjugation.
- 1H NMR spectral data of 250 products.
- Categorized and description of products for easy to understand.
  HPLC

 HPLC Columns - This catalog provides a comprehensive guide to our unique chromatography products including “TCI Chiral” of TCI original chiral separation columns, “TCI Dual” of ODS + Ion-Exchange Mixed-Mode columns and “TCI Pack and Kaseisorb” of high performance ODS columns.

A0001-25G

A0001-25G Abietic Acid

A5560-100MG

(S)-(+)-DBD-APy [=(S)-(+)-4-(N,N-Dimethylaminosulfonyl)-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] The compound A556 is an optically active HPLC fluorescence labeling reagent, which has a 2,1,3-benzoxadiazole skeleton and an amino group, and is used for optical purity determination of carboxylic acids. Labeling of racemic carboxylic acids can be done by using a mild condition such as the Mukaiyama-Corey method, and produces diastereomers without inducing racemization. These diastereomers can be separated by reversed phase HPLC, and an excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 47 nm and 58 nm, respectively. Since their excitation and fluorescence wavelengths are at longer wavelengths, detection has less interference by contaminants. A highly sensitive analysis can be done by peroxyoxalate chemiluminescence detection.

A5561-100MG

(R)-(-)-DBD-APy [=(R)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] The compound A5561 is an optically active HPLC fluorescence labeling reagent, which has a 2,1,3-benzoxadiazole skeleton and an amino group, and is used for optical purity determination of carboxylic acids. Labeling of racemic carboxylic acids can be done by using a mild condition such as the Mukaiyama-Corey method, and produces diastereomers without inducing racemization. These diastereomers can be separated by reversed phase HPLC, and an excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 47 nm and 58 nm, respectively. Since their excitation and fluorescence wavelengths are at longer wavelengths, detection has less interference by contaminants. A highly sensitive analysis can be done by peroxyoxalate chemiluminescence detection.

A5562-100MG

(S)-(+)-NBD-APy [=(S)-(+)-4-Nitro-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] The compound A5562 is an optically active HPLC fluorescence labeling reagent, which has a 2,1,3-benzoxadiazole skeleton and an amino group, and is used for optical purity determination of carboxylic acids. Labeling of racemic carboxylic acids can be done by using a mild condition such as the Mukaiyama-Corey method, and produces diastereomers without inducing racemization. These diastereomers can be separated by reversed phase HPLC, and an excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 47 nm and 54 nm, respectively. Since their excitation and fluorescence wavelengths are at longer wavelengths, detection has less interference by contaminants. A highly sensitive detection can be done by using laser induced fluorescence detector.

A5563-100MG

(R)-(-)-NBD-APy [=(R)-(-)-4-Nitro-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] The compound A5563 is an optically active HPLC fluorescence labeling reagent, which has a 2,1,3-benzoxadiazole skeleton and an amino group, and is used for optical purity determination of carboxylic acids. Labeling of racemic carboxylic acids can be done by using a mild condition such as the Mukaiyama-Corey method, and produces diastereomers without inducing racemization. These diastereomers can be separated by reversed phase HPLC, and an excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 47 nm and 54 nm, respectively. Since their excitation and fluorescence wavelengths are at longer wavelengths, detection has less interference by contaminants. A highly sensitive detection can be done by using laser induced fluorescence detector.

A5564-100MG

(S)-(-)-DBD-Pro-COCl [=(S)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] The compound A5564 is an HPLC fluorescence labeling reagent for optical purity determination, which easily reacts with optical active alcohols or amines to form the corresponding esters or amides, respectively. The resultant esters or amides are stable and can reach the detector without any decomposition under reversed and normal phase HPLC. An excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 45 nm and 56 nm, respectively. And the diastereomers derived from racemic alcohol and A5564 can be separated by HPLC (The separation factor α: 2-hexanol = 1.2). Since no racemization can occur with derivatization reaction, it is possible to change an elution order of the labeled diastereomeres by selecting the enantiomer [(R)-(+)-DBD-Pro-COCl] of A5564. The detection limit for the alcohols is sub-picomol.

A5565-100MG

(R)-(+)-DBD-Pro-COCl [=(R)-(+)-4-(N,N-Dimethylaminosulfonyl)-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] The compound A5565 is an HPLC fluorescence labeling reagent for optical purity determination, which easily reacts with optical active alcohols or amines to form the corresponding esters or amides, respectively. The resultant esters or amides are stable and can reach the detector without any decomposition under reversed and normal phase HPLC. An excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelength of 45 nm and 56 nm, respectively. And the diastereomers derived from racemic alcohol and A5565 can be separated by HPLC (The separation factor α: 2-hexanol = 1.2). Since no racemization can occur with derivatization reaction, it is possible to change an elution order of the labeled diastereomeres by selecting the enantiomer [(S)-(-)-DBD-Pro-COCl] of A5565. The detection limit for the alcohols is sub-picomol.

A5566-100MG

(R)-(+)-NBD-Pro-COCl [=(R)-(+)-4-Nitro-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] The compound A5566 is an HPLC fluorescence labeling reagent for optical purity determination, which easily reacts with optical active alcohols or amines to form the corresponding esters or amides, respectively. The resultant esters or amides are stable and can reach the detector without any decomposition under reversed and normal phase HPLC. An excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 47 nm and 54 nm, respectively. And the diastereomers derived from racemic alcohol or amine and A5566 can be separated by HPLC (The separation factor α: 2-hexanol and 1-phenylethylamine = 1.2 and 1.37, respectively). Since no racemization can occur with derivatization reaction, it is possible to change an elution order of the labeled diastereomeres by selecting the enantiomer [(S)-(-)-NBD-Pro-COCl] of A5566. The detection limit for the alcohols is sub-picomol. A highly sensitive detection can be done by using laser induced fluorescence detector.

A5567-100MG

(S)-(-)-NBD-Pro-COCl [=(S)-(-)-4-Nitro-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] The compound A5567 is an HPLC fluorescence labeling reagent for optical purity determination, which easily reacts with optical active alcohols or amines to form the corresponding esters or amides, respectively. The resultant esters or amides are stable and can reach the detector without any decomposition under reversed and normal phase HPLC. An excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 47 nm and 54 nm, respectively. And the diastereomers derived from racemic alcohol or amine and A5567 can be separated by HPLC (The separation factor α: 2-hexanol and 1-phenylethylamine = 1.2 and 1.37, respectively). Since no racemization can occur with derivatization reaction, it is possible to change an elution order of the labeled diastereomeres by selecting the enantiomer [(R)-(+)-NBD-Pro-COCl] of A5567. The detection limit for the alcohols is sub-picomol. A highly sensitive detection can be done by laser induced fluorescence detector.

A5568-100MG

(R)-(-)-DBD-Py-NCS [=(R)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(3-isothiocyanatopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [for HPLC Labeling] The compound A5568 is an HPLC fluorescence labeling reagent for optical purity determination. This compound easily reacts with amino or mercapto groups, which are directly linked to the asymmetric carbon atom and produces diastereomers of thiourea or dithiocarbamate. These diasteromers can be separated by reversed phase HPLC, and an excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 46 nm and 55 nm, respectively. [The detection limit: thiopronine = .5 pmol (S/N = 2)] Since both (R)- and (S)-isomers of the derivatization reagents are commercially available on the market, it is possible to change an elution order of the derivatized diastereomers by selecting either enantiomer of the derivatization reagent. Thus, an enantiomer of the amino-compound, whose existing quantity is very small, can be eluted out first and quantified with a high precision. Moreover, there are reports for the application of these isomers to Edman Degradation.

A5569-100MG

(S)-(+)-DBD-Py-NCS [=(S)-(+)-4-(N,N-Dimethylaminosulfonyl)-7-(3-isothiocyanatopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [for HPLC Labeling] The compound A5569 is an HPLC fluorescence labeling reagent for optical purity determination. This compound easily reacts with amino or mercapto groups, which are directly linked to the asymmetric carbon atom and produces diastereomers of thiourea or dithiocarbamate. These diasteromers can be separated by reversed phase HPLC, and an excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 46 nm and 55 nm, respectively. [The detection limit: thiopronine = .5 pmol (S/N = 2)] Since both (R)- and (S)-isomers of the derivatization reagents are commercially available on the market, it is possible to change an elution order of the derivatized diastereomers by selecting either enantiomer of the derivatization reagent. Thus, an enantiomer of the amino-compound, whose existing quantity is very small, can be eluted out first and quantified with a high precision. Moreover, there are reports for the application of these isomers to Edman Degradation.

A5569-500MG

(S)-(+)-DBD-Py-NCS [=(S)-(+)-4-(N,N-Dimethylaminosulfonyl)-7-(3-isothiocyanatopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [for HPLC Labeling] The compound A5569 is an HPLC fluorescence labeling reagent for optical purity determination. This compound easily reacts with amino or mercapto groups, which are directly linked to the asymmetric carbon atom and produces diastereomers of thiourea or dithiocarbamate. These diasteromers can be separated by reversed phase HPLC, and an excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 46 nm and 55 nm, respectively. [The detection limit: thiopronine = .5 pmol (S/N = 2)] Since both (R)- and (S)-isomers of the derivatization reagents are commercially available on the market, it is possible to change an elution order of the derivatized diastereomers by selecting either enantiomer of the derivatization reagent. Thus, an enantiomer of the amino-compound, whose existing quantity is very small, can be eluted out first and quantified with a high precision. Moreover, there are reports for the application of these isomers to Edman Degradation.

A5573-100MG

NBD-CO-Hz [=4-(N-Hydrazinocarbonylmethyl-N-methylamino)-7-nitro-2,1,3-benzoxadiazole] [for HPLC Labeling] The compound A5573, an HPLC fluorescence labeling reagent, which has a 2,1,3-benzoxadiazole skeleton and a hydrazino group, easily reacts with a carboxyl group to form the corresponding carbohydrazide in the presence of a condensing agent. The resultant carbohydrazide is stable for at least one week at 4 ºC. The carbohydrazide derivatives can be analyzed by reversed phase HPLC, and an excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 475 nm and 53 nm, respectively. [The detection limit = 2~4 fmol (S/N = 3)]

A5574-100MG

DBD-ED [=4-(N,N-Dimethylaminosulfonyl)-7-(2-aminoethylamino)-2,1,3-benzoxadiazole] [for HPLC Labeling] The compound A5574, an HPLC fluorescence labeling reagent, which has a 2,1,3-benzoxadiazole skeleton and an amino group, easily reacts with a carboxyl group to form the corresponding amide in the presence of a condensing agent. The resultant amide is stable enough to reach the detector without any decomposition under reversed phase HPLC. An excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 45 nm and 56 nm, respectively. Since their excitation and fluorescence wavelengths are at longer wavelengths, detection has less interference from contaminants. Short-chain fatty acids are detectable and determinable reproducibly with a detection limit on the order of fmol. A highly sensitive detection can be done by using chemiluminescence

A5575-100MG

DBD-NCS [=4-(N,N-Dimethylaminosulfonyl)-7-isothiocyanato-2,1,3-benzoxadiazole] [for HPLC Labeling and Edman Degradation] The compound A5575 is an HPLC fluorescence labeling reagent, which has a 2,1,3-benzoxadiazole skeleton and an isothiocyano group, and easily reacts with an amino group to form the corresponding thiourea. The resultant thiourea is stable enough to reach the detector without any decomposition under reversed phase HPLC. An excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 384 nm and 52 nm, respectively. The detection limit for its quantity is an order of sub-picomol (S/N = 3). A5575 itself does not fluoresce but shows an excellent stability in forms of both crystal and solution, and its derivatives are also stable. This compound can be used for amino acid sequence analysis (Edman Degradation) by binding with the N-terminal amino acid of peptides or proteins, followed by acid treatment.

A5577-100MG

(R)-(-)-NBD-Py-NCS [=(R)-(-)-4-(3-Isothiocyanatopyrrolidin-1-yl)-7-nitro-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] The compound A5577 is an HPLC fluorescence labeling reagent for optical purity determination. This compound easily reacts with amino groups, which are directly linked to an asymmetric carbon atom, and produces diastereomers of thiourea. These diasteromers can be separated by reversed phase HPLC, and an excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 488 nm and 59 nm, respectively. Since both (R)- and (S)-isomers of the derivatization reagents are commercially available on the market, it is possible to change the elution order of the derivatized diastereomers by selecting either enantiomer of the derivatization reagent. Thus, an enantiomer of the amino-compound, whose existing quantity is very small, can be eluted out first and quantified with high precision. Moreover, there are reports for the application of these isomers to Edman Degradation. market, it is possible to change the elution order of the derivatized diastereomers by selecting either enantiomer of the derivatization reagent. Thus, an enantiomer of the amino-compound, whose existing quantity is very small, can be eluted out first and quantified with high precision. Moreover, there are reports for the application of these isomers to Edman Degradation.

A5578-100MG

(S)-(+)-NBD-Py-NCS [=(S)-(+)-4-(3-Isothiocyanatopyrrolidin-1-yl)-7-nitro-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] The compound A5578 is an HPLC fluorescence labeling reagent for optical purity determination. This compound easily reacts with amino groups, which are directly linked to an asymmetric carbon atom, and produces diastereomers of thiourea. These diasteromers can be separated by reversed phase HPLC, and an excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 488 nm and 59 nm, respectively. Since both (R)- and (S)-isomers of the derivatization reagents are commercially available on the market, it is possible to change the elution order of the derivatized diastereomers by selecting either enantiomer of the derivatization reagent. Thus, an enantiomer of the amino-compound, whose existing quantity is very small, can be eluted out first and quantified with high precision. Moreover, there are reports for the application of these isomers to Edman Degradation.

A5593-100MG

NBD-F (=4-Fluoro-7-nitro-2,1,3-benzoxadiazole) [for HPLC Labeling] The compound A5593 which is an HPLC fluorescence labeling reagent having a 2,1,3-benzoxadiazole skeleton, can easily react with amino or mercapto groups to form the corresponding derivatives. A5593 itself does not fluoresce, and its ethanol solution is relatively stable for a week in a refrigerator. The derivatives can reach the detector without any decomposition under reversed phase HPLC. An excellent chromatogram can be obtained by fluorescence detection at the excitation and emission wavelengths of 47 nm and 53 nm, respectively. Since their excitation and fluorescence wavelengths are at longer wavelengths, detection has less interference by contaminants. Thus, further highly sensitive detection can be done by using laser induced fluorescence detector. When the reagent is hydrolyzed (NBD-OH), its fluorescence can be erased under an acidic condition. Therefore, this hydrolyzed reagent can be used as a post column reaction reagent

A0001-500G

A0001-500G Abietic Acid

A0002-25G

Ethyl Abietate