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Clarity BioSolutions is a range of chromatography columns and solutions designed for the purification and analysis of synthetic oligonucleotides, including DNA, RNA, siRNA, aptamers, and modified or labeled oligonucleotides. Clarity products are developed to meet the needs of biological research, therapeutic development, and biopharmaceutical manufacturing.
Clarity columns provide high separation efficiency and enable the separation of target oligonucleotides from structurally similar impurities, including n−1 sequences. The product range includes solutions for analytical and preparative chromatography, quality control, and LC-MS analysis.
Key Benefits of Clarity
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High resolution — Efficient separation of target oligonucleotides from structurally similar impurities, including n−1 sequences.
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Designed for DNA and RNA analysis — Solutions for the analysis and purification of synthetic oligonucleotides, RNAi molecules, aptamers, phosphorothioate oligonucleotides, and modified sequences.
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High LC-MS performance — Specialized stationary phases provide rapid separation, sharp peaks, and high sensitivity in oligonucleotide analysis.
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Core-Shell Technology — Oligo-XT and Oligo-MS columns feature solid-core particles with a porous outer layer, delivering high separation efficiency and reduced peak broadening.
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Scalable purification — Selected product lines allow methods to be scaled from analytical to preparative chromatography for target compound isolation and purification.
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Broad oligonucleotide length coverage — Solutions for analyzing sequences of up to 60 nucleotides, depending on the product line and application.
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Stability under various analytical conditions — Selected product lines offer a wide operating pH range and compatibility with 100% aqueous mobile phases.
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Selectable chromatographic selectivity — Different stationary phases allow separation, analysis speed, and sensitivity to be optimized for specific applications.
Clarity Oligo-XT — High Efficiency and Scalability
Core-Shell columns designed for analytical and preparative oligonucleotide separation. They deliver high efficiency, rapid separations, and sensitivity. They are stable across a pH range of 1–12 and compatible with 100% aqueous mobile phases.
Clarity Oligo-MS — For Rapid LC-MS Analysis
Core-Shell columns developed for high-efficiency oligonucleotide analysis using liquid chromatography–mass spectrometry (LC-MS). They are suitable for quality control, complex mixture characterization, and rapid impurity separation. The operating pH range is 1.5–8.5.
Clarity Oligo-RP — For Oligonucleotide Analysis and Purification
Columns with reversed-phase selectivity designed for the separation and purification of synthetic DNA, RNA, and modified oligonucleotides. They enable differentiation between target sequences and synthesis by-products. Their specialized sorbent structure combines high loading capacity with scalability from analytical to preparative chromatography. The operating pH range is 1–12.
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