Shodex polymer-based HPLC columns

Shodex offers a comprehensive range of high-performance HPLC columns with a strong focus on polymer-based stationary phases. These phases provide unique and alternative selectivity, enabling challenging analytical separations where conventional silica-based columns may not provide sufficient performance or selectivity.

The Shodex portfolio covers the major liquid chromatography separation modes, including Reversed Phase, HILIC, Ligand Exchange, Ion Exclusion, Ion Chromatography, Aqueous SEC, Organic GPC, Ion Exchange, and Chiral Separation. This broad range enables specialized solutions for the analysis of pharmaceuticals, food products, sugars, organic acids, ions, synthetic polymers, proteins, antibodies, polysaccharides, DNA/RNA, and other challenging analytes.

Key Advantages 

• Expertise in polymer-based stationary phases — polymeric packing materials provide alternative selectivity and expand HPLC capabilities for challenging analytical applications.
• Wide range of separation mechanisms — RP, HILIC, SEC/GPC, ion chromatography, ion exchange, ligand exchange, ion exclusion, and chiral chromatography within a single portfolio.
• Effective analysis of polar compounds — a broad selection of HILIC phases with different functional groups allows selectivity to be optimized for sugars, small charged molecules, and other highly polar analytes.
• Specialized solutions for sugar analysis — the SUGAR series uses different counterions, including Pb²⁺, Ca²⁺, Na⁺, and Zn²⁺, for selective analysis of mono-, di-, and oligosaccharides.
• Extensive SEC/GPC capabilities — specialized series are designed for the separation of water-soluble macromolecules such as proteins, antibodies, polysaccharides, and polymers, as well as synthetic polymers, plastics, and resins soluble in organic solvents.
• Solutions for biomolecules — SEC and ion-exchange columns enable the analysis of proteins, peptides, antibodies, DNA, RNA, nucleotides, and amino acids.
• Solutions for ionic analysis — specialized IC columns are designed for the determination of anions and cations, including applications involving aqueous samples.
• Specialized solutions for organic acids — ion-exclusion columns are suitable for routine analysis of organic acids and mixtures of organic acids and saccharides in food products and fermentation samples.
• Versatile application range — Shodex columns cover pharmaceutical, biopharmaceutical, food, environmental, and polymer analysis.
• Specialized solutions for challenging applications — the portfolio includes columns for the analysis of PFAS, antibodies, polymers, glyphosate, carbohydrates, organic acids, and other specific analyte groups.

Main Types of Shodex Columns

Reversed Phase — Reversed-Phase Chromatography
Columns for the analysis of non-polar compounds, including pharmaceuticals, biomolecules, and food components. Shodex polymer-based RP phases provide alternative selectivity for HPLC method development and optimization.

HILIC — Hydrophilic Interaction Liquid Chromatography
Polymer-based phases with different functional groups for effective retention and separation of polar compounds, including sugars and small charged molecules.

SUGAR — Ligand Exchange Chromatography
Specialized columns with Pb²⁺, Ca²⁺, Na⁺, or Zn²⁺ counterions for routine analysis of mono-, di-, and oligosaccharides and other carbohydrates.

Organic Acids — Ion Exclusion Chromatography
Columns for routine determination of organic acids and analysis of mixtures containing saccharides and organic acids, particularly in food products and fermentation samples.

Aqueous SEC — Aqueous Size Exclusion Chromatography
Columns for size-based separation of water-soluble macromolecules, including proteins, antibodies, polysaccharides, and polar polymers.

Organic GPC — Gel Permeation Chromatography
Specialized columns for the separation and determination of molecular weight distribution of synthetic polymers, plastics, and resins soluble in organic solvents.

Ion Chromatography
Columns for the determination of anions and cations, including specialized solutions for water analysis.

Ion Exchange — Ion-Exchange Chromatography
Anion- and cation-exchange columns for the separation of charged compounds and biomolecules, including proteins, peptides, DNA, RNA, nucleotides, and amino acids.

Chiral — Chiral Chromatography
Cyclodextrin-derivative-based columns for the separation of isomers and chiral pharmaceutical compounds.